180 Life Sciences Corporate Media Kit

30 CBD - A Superior Treatment For Arthritis Problem • Very early arthritis, pain & swelling is not effectively treated clinically • Nonsteroidals do not help, can increase TNF (1) • Existing therapies are suboptimal: ─ Methotrexate has side effects patients dislike ─ Anti-TNF is costly and use restricted / delayed by NICE (National Institute of Clinical Evidence, in UK) ─ Early rheumatoid or psoriatic arthritis is badly treated: delays mean the "window of opportunity" for best results is missed Solution • For very early arthritis: novel SCAs being developed • Effective anti-inflammatory (better than NSAIDs) • Effective analgesic • For early established RA, PsA: SCA will be tried in combination (offers additional patentability) • Trials will be performed by Oxford rheumatologists and trial experts Oral CBD is effective in mouse model of RA From the first clinical signs of arthritis, mice were given CBD orally , at the following doses: 50 mg/kg ( △ ), 25mg/kg ( ▲ ), or 10 mg/kg (o). A. M. Malfait, R. Mechoulam, M. Feldmann, R. Gallily PNAS 2000;97:17:9561-9566 CBD reduces inflammation in knee arthritis – unpublished new data CBD was administered intraperitoneally to mice with zymosan induced arthritis in the left knee. Inflammation intensity is marked by colour scale shown on right, using a fluorescent reporter of cathepsin. CBD (5-25 mg/kg) attenuates local inflammation in a dose dependent manner. (1) Page TH …… & Feldmann M (2010), J Immunol.15;185(6):3694-701 180 Life Sciences Corp. www.180lifesciences.com Q4 2020