180 Life Sciences Corporate Media Kit

33 SCA & α7nAChR Program Patents SCA: CYCLOHEXENYL COMPOUNDS, COMPOSITIONS COMPRISING THEM AND USES Country Application No. Date Filed/Granted Status Note US2 10239848 26/03/2019 Granted Claims directed to a method for treating obesity or a disease/disorder associated therewith by administration of a compound of the formula as defined in claim 1 – issued. US3 16/274,107 12/02/2019 Filed Claims directed to a method for treating pain or associated condition or symptom by administration of a compound of the formula as defined in claim 1 IL 248256 31/07/2018 Granted Claims directed to a pharmaceutical composition for treatment of (i) obesity or a disease/disorder associated therewith; or (ii) abnormal food consumption or body weight, or a condition or symptom associated therewith, comprising a compound of the formula 1 as defined in claim 1 EP 15726740.2 09/08/2016 Filed CN ZL20158002097 8.7 14/01/2020 Granted CA 2944837 Filed SCA: BIOACTIVE PHENOLATE IONIC COMPLEXES Country Application No. Date Filed/Granted Status Note US 62/704,121 22/04/2020 Filed α7nAChR Country Date Filed/Granted Status Patent/Application Number Note US Grant 16/09/2014 Granted US8835391B2 Alpha B-crystallin as a therapy for multiple sclerosis US Grant 25/01/2011 Granted US7875589B2 Alpha B-crystallin as a therapy for rheumatoid arthritis US Grant 08/07/2014 Granted US8771689B2 Alpha B-crystallin as a therapy for ischemia or inflammation US Application 16/09/2019 Filed US20180333451A1 B-1a lymphocyte and/or macrophage targeting and activation to treat medical conditions with inflammatory or autoimmune components. Japan 18/11/2016 Filed 2018-526196 B-1a lymphocyte and/or macrophage targeting and activation to treat medical conditions with inflammatory or autoimmune components. Canada 18/11/2016 Filed 3004908 B-1a lymphocyte and/or macrophage targeting and activation to treat medical conditions with inflammatory or autoimmune components. STATUS OF PATENT APPLICATIONS UPDATED Sept 20, 2020 CANN-001 – Cyclohexenyl compounds, compositions comprising them and uses thereof (HU436 & HU435) Applicant: Yissum research development company of the Hebrew University of Jerusalem Ltd. Inventors: Ruth Gallily, Raphael Mechoulam, Aviva Breuer Priority: US Provisional Application No. 61/981,997, filed April 21, 2014 (expired) 180 Life Sciences Corp. www.180lifesciences.com Q4 2020