AzurRx (AZRX) Corporate Media Kit

20 20 Note: In normal subjects, physiological pH in duodenum is between approximately 5 and 6. In CP and CF pH is lowered to a more acidic range, approximately pH 4 to 5. MS1819 not inactivated by bile salts. SA (U/mg of purified enzyme equivalent 0 2,000 4,000 6,000 8,000 10,000 12,000 14,000 2 3 4 5 6 7 8 9 pH MS1819 Porcine PERT Basic Acidic MS1819 Lipase Porcine Pancreatic Lipase MS1819 lipase shows superior activity to porcine lipase at the relevant intestinal pH range of 4 to 6 Healthy Patients CF Patients MS1819 Shows Strong Activity at Normal pH Range In vitro lipolytic activity of MS1819 lipase in the presence of bile salts in the European and US Pharmacopeia test (U/mg, Pure Enzyme)