AzurRx (AZRX) Corporate Media Kit

21 21 PPI:Proton-pump inhibitors Source: Results of interviews of 10 pulmonologists, The CorStar Group 5/2019, and 10 gastroenterologists, Campbell Alliance 8/2014 Presenting CF Patient (often at birth) Treatment and Therapy Options Mild (25%, ~7K) Moderate (42%, ~11K) Severe (33%, ~9K) Diet Modification Fat Soluble Vitamin Supplementation PERTs Diet Modification Fat Soluble Vitamin Supplementation PPIs PERTs Diet Modification Fat Soluble Vitamin Supplementation PPIs PERTs 2 nd Line (10%) 1 st Line (25%) (Percent ending line of therapy) 2 nd Line (75%) 1 st Line (100%) 1 st Line (90%) CF Treatment Approach CF EPI patients progress through different lines of therapy. Progressive EPI requires enzyme replacement therapy to treat the underlying deficiency.