Predictive Oncology (POAI) Twitter and Facebook Letter

2915 Commers Drive, Suite 900 Eagan, MN 55121 651.389.4800 phone ● 651.389.4801 fax Dear Shareholder, Our Special Meeting of the Shareholders on December 1, 2020 was adjourned to December 30, 2020. We need your vote! We are asking you to vote for allowing the Company to reincorporate in the state of Nevada, moving away from Delaware. Our Board believes that there are several reasons why a reincorporation in Nevada is in the best interests of the Company and our stockholders. First and foremost, the reincorporation in Nevada will eliminate our obligation to pay the injurious annual Delaware franchise tax, which is currently equal to approximately $170,000 per year. We can save approximately $158,000 annually in state taxes by reincorporating in Nevada. Also, we believe that for the reasons described in the proxy materials, in general, Nevada law provides greater protection to our directors, officers and the Company than Delaware law. Your vote is very important, regardless of the number of shares you own. The reincorporation, to be approved at the Special Meeting, must receive a “For” vote from a majority of the outstanding shares of common stock of the Company. At our recent Annual Meeting, the Reincorporation vote received far more “For” votes than “Against” votes, however, we did not reach the required number of total votes for a majority of the outstanding shares. Please take a moment to vote your shares by following the instructions in your proxy materials. You may vote online or by telephone. Thank you for your cooperation and support.