Tryp Therapeuatics (TRYPF) Coverage Report

Exhibit 22: Model of interacting mechanisms involved in the development of CRPS IL = interleukin; SNS = sympathetic nervous system; TNF = tumor necrosis factor; Source: BMJ. 2015; 351: h2730 Michael Higgins 212.409.2074 Tryp Therapeutics, Inc. (TRYPF) Page 30