VistaGen Therapeutics Company Presentation

www.vistagen.com 12 ƒ Microgram level intranasal dose (3.2 mcg) engages specific nasal chemosensory neurons (NCNs) ƒ NCNs activate olfactory bulb neurons (OBNs) on the base of the brain ƒ OBNs send neural connections specifically to neurons in the central limbic amygdala, the brain center where fear and anxiety are regulated ƒ Neurons in the limbic amygdala modulate inhibitory neurotransmitters, resulting in rapid anti-anxiety effects ƒ Systemic uptake and distribution of 3.2 mcg dose not required to produce rapid-onset anti-anxiety effects PH94B’s Mechanism of Action – “Action from a Distance”