VistaGen Therapeutics Company Presentation

www.vistagen.com 26 ƒ Microgram level dose (6.4 mcg) engages specific nasal chemosensory neurons (NCNs) ƒ NCNs activate olfactory bulb neurons (OBNs) on the base of the brain ƒ OBNs send neural connections to neurons in the central limbic amygdala, the brain center where mood is regulated ƒ Neurons in the limbic amygdala stimulate release of excitatory neurotransmitters (glutamate, norepinephrine) resulting in rapid-onset antidepressant effects ƒ Systemic uptake and distribution not required to produce rapid-onset antidepressant effects PH10 Mechanism of Action – Action from a Distance